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產(chǎn)品規(guī)格
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BN41837R-50ul
50ul
￥1486.00
交叉反應：Rat,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Mouse) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41837R-100ul
100ul
￥2360.00
交叉反應：Rat,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Mouse) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
BN41837R-200ul
200ul
￥3490.00
交叉反應：Rat,Human(predicted:Rabbit,Horse,Cow,Pig,Dog,Mouse) 推薦應用：IHC-P,IHC-F,IF,Flow-Cyt,ELISA
產(chǎn)品描述
| 英文名稱 | Fbx32 |
| 中文名稱 | 泛素蛋白連接酶抗體 |
| 別 名 | Fbx32; 4833442G10Rik; AI430017; Atrogin 1; Atrogin-1; ATROGIN1; Atrophy gene 1; F box only protein 32; F-box only protein 32; F-box protein 32; FBX32_HUMAN; fbxo25; FBXO32; FLJ32424; MAFbx; MGC108443; MGC137646; MGC33610; Muscle atrophy F box; Muscle atrophy F box protein; Muscle atrophy F-box protein. |
| 研究領域 | 細胞生物 干細胞 泛素 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應 | Human, Rat, (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, ) |
| 產(chǎn)品應用 | ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2ug/test IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 42kDa |
| 細胞定位 | 細胞核 細胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human MAFbx:31-130/355 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | Fbx32 is an E3 ubiquitin ligase that initiates ATP dependent ubiquitin-mediated proteolysis and promotes muscle atrophy. It is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. It is also thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. Fbx32 interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD. Function: Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. Subunit: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32. Subcellular Location: Cytoplasm. Nucleus. Note=Shuttles between Cytoplasm and the nucleus. Tissue Specificity: Specifically expressed in cardiac and skeletal muscle. Similarity: Contains 1 F-box domain. SWISS: Q969P5 Gene ID: 114907 Database links: Entrez Gene: 114907 Human Entrez Gene: 67731 Mouse Omim: 606604 Human SwissProt: Q969P5 Human SwissProt: Q9CPU7 Mouse Unigene: 403933 Human Unigene: 292042 Mouse Unigene: 72619 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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